Afdhal et al. New England Journal of Medicine.
Perspective: Obesity is not a Disease [open access]
DL Katz. Nature.
Chronic Pain, Addiction, and Zohydro [open access]
Olsen and Sharfstein. NEJM.
Nature Outlook: Antibiotics
Free open access collection of articles.
Game Changers for ATTR Amyloidosis
Dr. Jeffrey Zonder (Amyloid Planet)
Not actually a journal article but a very science-heavy blog post (ISIS, ALNY).
Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation [open access]
Kariya et al. Journal of Clinical Investigation.
Interesting preclinical paper relevant to BIIB-ISIS Spinal Muscular Atrophy (SMA) program.
The Evolution of Amidine-based brain penetrant BACE1 inhibitors [open access]
Oehlrich et al. Bioorganic & Medicinal Chemistry Letters.
Review related to the (current) most advanced Alzheimer's Disease therapeutic target (MRK, LGND, AZN).