Kingwell et al. Nature Reviews Drug Discovery.
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
The TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute. New England Journal of Medicine. [open access]
Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
Jorgensen et al. NEJM. [open access]
The two papers above drove much conversation in the biotech world, including a major New York Times feature. Key stocks in the discussion included ISIS and AMRN.
Open Clinical Trial Data for All? A View from Regulators
Eichler et al. PLOS Medicine. [open access]
Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes
Russell et al. New England Journal of Medicine. [open access]
The publication of these studies was the defining diabetes story of the year (or at least until Mannkind $MNKD received approval for their inhaled insulin product Afrezza).
Nature Outlook: Stroke
Collection of Nature scientific / medical articles that are fully accessible for free.