I am pleased to report that the Pipelines page has been completely updated over the past couple days. This feature highlights the latest links and files related to clinical research and development pipeline progress for major biotech and pharmaceutical companies. More and more, I am trying to host PDF files of the pipeline status rather than just a website link, in order to better preserve the historical context. I hope you find this resource useful and I welcome any feedback.
Cancer: Unpronounceable Drugs, Incomprehensible Prices
Who's Afraid of Peer Review?
John Bohannon. Science.
New Expensive Treatments for Hepatitis C Infection
Troyen Brennan. Journal of the American Medical Association. $GILD
Niacin and HDL Cholesterol — Time to Face Facts
Donald Lloyd-Jones. New England Journal of Medicine.
Group seeks standardization for what clinical trials must measure
Amanda Keener. Nature Medicine.
Emergence of Zaire Ebola Virus Disease in Guinea — Preliminary Report
Sylvain Baize et al. NEJM. $TKMR $SRPT
The strain isolated in Guinea and studied by these researchers is in fact new.
The Coming Human Body On A Chip That Will Change How We Make Drugs
Jessica Leber (Fast Co Exist)
On the search for non-animal alternatives for predicting drug effects / toxicology in humans.
How Well Does A Drug Work? Look Beyond The Fine Print
National Public Radio
Can we improve drug labeling so patients actually understand how well the drug works, compared to what, and with what side effects?
These Medical Apps Have Doctors and the FDA Worried
Robert McMillan (Wired)
Does Valeant’s Cost-Cutting Go Too Far?
Jesse Eisenger (ProPublica) $VRX $AGN
With $2M Seed, Perlstein Lab Tests Unorthodox Rare-Disease Plan
Alex Nash (Xconomy) $RTRX
Interview: Steve Yang (WuXi AppTec) on the Chinese biotech industry
Nature Outlook: Epilepsy [collection of free articles]
Clinical Trial Transparency — Antidote to Weaker Off-Label-Promotion Rules?
Keith Outterson. New England Journal of Medicine.
U.S. Food and Drug Administration Inspections of Clinical Investigators: Overview of Results from 1977 to 2009.
Morgan-Linnell et al. Clinical Cancer Research.
Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks
Stephen Strittmatter. Nature Medicine.
Drug Companies' Patient-Assistance Programs — Helping Patients or Profits?
David Howard. New England Journal of Medicine.
FDA sets hierarchy for biosimilars evidence
Mark Ratner. Nature Biotechnology.