Highlights from Spectrum Pharma $SPPI investor event (excerpts c/o SeekingAlpha) with updated commentary on every major development / commercial product. For archival purposes (June 2013)
The first part of my summary of news and notes from Spectrum Pharma's year-end earnings conference call focused on apaziquone, the bladder cancer drug that missed in phase 3 and was recently returned by partner Allergan. You can read SPPI Part 1 here.
Part 2 will cover other highlights, particularly regarding Fusilev and Zevalin. Of course all of these comments should be taken with a grain of salt given the bombshell press release SPPI released a couple weeks later. In some cases the change in commentary in such a short period of time is very difficult to reconcile.
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Spectrum Pharma SPPI recently held their fourth-quarter and full-year 2012 earnings call. Topics of discussion included each of the marketed or late-stage cancer drugs: FUSILEV, ZEVALIN, FOLOTYN, belinostat, and apaziquone.
In this Part 1 post, I am including highlights from the SPPI and (former) partner Allergan AGN's earnings calls regarding apaziquone.
(continue reading full post for details)
TopoTarget (partner of Spectrum Pharma $SPPI) conference call notes - belinostat in CUP trial results
TopoTarget is a European biotech company that licensed the histone deacetylase (HDAC) inhibitor belinostat to Spectrum Pharma $SPPI. In June 2012 Topo released top-line data for the clinical trial in cancer of unknown primary (CUP) - belinostat failed to achieve the primary endpoint of an increase in progression-free survival (PFS). A secondary endpoint of objective response rate (ORR) was positive and statistically significant.
The company then held a conference call to explain the results and justify to shareholders why they shouldn't view this as a failure. They even went so far as to release a further press release in August 2012 with some new data-mining. This sort of behavior is typical of small biotech companies heavily reliant on the fate of a single drug, and diligent biotech investors must recognize this and not invest in a company advancing a drug out of necessity or convenience vs. actual clinical and commercial potential.
My notes from the conference call continue below the jump.
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